Drugs Most Important MCQs

1 - A 50 year old female with end stage renal disease (ESRD) develops pulmonary tuberculosis. Which one of the following drugs should be used in a reduced dose ?






Ethambutol

2 - A common side effect associated with all NSAID drugs is_______________?






Gastric irritation

3 - A Hemophiliac patient has rheumatold arthritis. Which drug might be prescribed to relieve the pain ?






Acetaminophen

4 - A paralyzing dose of succinylcholine initially elicits______________?






Muscle fasciculation

5 - A patient is having bronchodilation, increased temperature, constipation and tachycardia. The tentative diagnosis is_______________?






Atropine poisoning

6 - A patient on 300 mg of aspirin will show all the following except________________?






Irreversible inhibition of cyclooxygenase path way

7 - A patient taking beta-blocker preoperatively, at induction of anaesthesia with fentanyl. Which muscle relaxant should be avoided ?






Pancuronium

8 - A patient with grand mal epilepsy would likely be under treatment with_____________?






Phenytoin

9 - A patient with grandmal epilepsy would likely be under treatment with_______________?






Phenytoin

10 - A person with glaucoma should not receive________________?






Antisialogogues

11 - A young lady talking rifampicin and OCP together become pregnant, most probable cause is____________?






Rifampicin causes hepatic enzyme induction and increase metabolism of OCP's

12 - About heparin true is_____________?






Half-life is 90 min

13 - Action of Nitroglycerin is______________?






Direct action on smooth muscle

14 - Activation of which of the following receptors would be expected to decrease anxiety_____________?






GABA receptors

15 - Acute Barbiturate poisoning results in_______________?






Respiratory failure

16 - Adrenaline is used in following EXCEPT______________?






Both B & C

17 - Agents/Drugs which help in rapid coagulation of Blood_______________?






All of the above

18 - All are symptoms of opiate withdrawls except______________?






Excessive speech

19 - All are true about metformin except_____________?






Used in decompensated heart failure

20 - All are true about nitric oxide, EXCEPT____________?






Acts via cAMP

21 - All are true of diazapenes except____________?






Benzodiazepam is used in the long term treatment of psychic disorders

22 - All NSAIDs block cycloxygenase and____________?






Prostaglandin synthesis

23 - All of the following are endogenous corticosteriods released by all adrenal cortex EXCEPT______________?






Dexamethsone

24 - All of the following are predominant arteriolar dilators except____________?






Nitrates

25 - All of the following are true about tolbutamide except____________?






It is used in type-I diabetes mellitus

26 - All of the following decrease skeletal muscle tone by CNS effects except____________?






D-tubocurarin

27 - All of the following drugs are useful in treatment of hypertension except______________?






Ephedrine

28 - All of the following glucocorticorticoids can be given by inhalation EXCEPT_______________?






Dexamethasone

29 - All of the following have receptors which are transcription factors except____________?






Insulin

30 - All of the following statements about opioids is correct except_____________?






Partial agonists are free from classic opioid adverse effects

31 - All of the following statements about pain are correct except_____________?






Naloxane is a non-competitive antagonist and irreversibly opposes the opioids

32 - All of the given drugs are positive inotropes EXCEPT_____________?






Doxepin

33 - All of the given drugs may be useful in acute exacerbation of bronchial asthma EXCEPT_____________?






Ipratropium

34 - All the following about antiemetic drugs are correct except_______________?






Ondastran may cause vomiting by effecting the cytotoxic antige receptors

35 - All the following drugs reduced the gastric acid secretion EXCEPT____________?






Sucralfate

36 - Alpha blocker used as anti hypertensive agent_____________?






Prazosin

37 - Amitryptyline is a____________?






Tricyclic antidepressant

38 - Amyl nitrate is most commonly administered _________________?






Sub lingually

39 - An antiepileptic drug used in petitmal epilepsy is______________?






Ethosuximide

40 - An anxiolytic, not interacting with GABA ergic system and used in generalized anxiety is______________?






Buspiron

41 - An attack of bronchial asthma is most likely to be triggered by________________?






Both A & B

42 - An attack of migraine can be easily terminated by___________?






Ergotamine

43 - An oral hypoglycemic agent is______________?






Glibeneclamide

44 - An untoward effect of that is common to all phenothiazines is______________?






Rigidity and tremor at rest, particularly with prolonged use

45 - Antagonist of morphine is_______________?






Naloxone

46 - Aspirin acts on which part of brain ?






Substantia gelatinosa

47 - Aspirin causes___________?






Hypoprothrombinemia

48 - Aspirin is avoided in children with influenza infection because of association______________?






Reye's syndrome

49 - Aspirin is contraindicated in______________?






All of the above

50 - Aspirin is contraindicated in_______________?






Peptic ulcer

51 - Aspirin is used in treatment of Myocardial Infarction___________?






It inhibits thromboxanes

52 - Aspirin produces all of the following effects except_____________?






Constipation

53 - Aspirine cause_____________?






Increase BT

54 - Aspirine is useful in all the following conditions EXCEPT_____________?






Gout

55 - Atropine is used in______________?






Organophosphate poisoning

56 - Atypical Antipsychotic are all except______________?






Thioridazone

57 - B- blocker with additional a-blocking property is____________?






Labetalol

58 - Benzodiazepine antagonist is________________?






Flumazenil

59 - BEnzodiazepines are true in___________________?






More safe than other sedatives when take in larger amounts

60 - Best and most effective drug to control convulsions in toxicity cases is______________?






Diazepam

61 - Beta blockers are contraindicated in___________?






Cardiac failure

62 - Beta2 adrenergic receptor stimulating drugs are used in_______________?






Bronchial asthma

63 - Birbiturates in pediatrics is_____________?






Low safety

64 - Bleeding from the oral mucosa can be reduced by topical use of_______________?






Epinephrine

65 - Blockers are used in all except_____________?






Thyrotoxcosis

66 - Bradycardia is most commonly treated with which of the following drugs_____________?






Atropine

67 - Bronchospasm can be precipitated by______________?






propranolol

68 - Buprenorphine acts by following mechanism________________?






Mu receptor partial agnoist

69 - Carbamazepine is a type of___________?






Antidepressant

70 - Cloidogrel is an______________?






Antipalatelet

71 - Clotting time is most like to be prolonged by the administration of____________?






Acetyl salicylic acid

72 - Curare poisoning is characterised by________________?






Hypotension

73 - Delay in blood coagulation results from_____________?






Heparin

74 - Diuretics cause loss of_______________?






Potassium

75 - Doalin pectrose is_____________?






Anti diarroheal

76 - DOPA and 5-Hydroxytryptophan are clinically important because_____________?






They cross blood Brain Barriers

77 - Drug not requiring dose adjustment in renal disease is___________?






Calcium channel blocker

78 - Drug that does not cause sedation________________?






Buspirone

79 - Drug which causes gingival hyperplasia_____________?






Both A & C

80 - Drug which is used to control status epilepticus is______________?






Diazepam

81 - Drugs causing hyperglycemia_______________?






Glucocorticoids

82 - Drugs like barbiturates precipitate symptoms of prophyria because______________?






They depress ALA synthase

83 - Dry mouth during antidepressant therapy is caused by blockade of______________?






Muscarinic acetylcholine receptors

84 - D-tubocurarine blocks the neuromuscular transmission by___________?






Blocking acetylcholine receptors

85 - Each of the following is correct for the treatment of Diarrhoea except_______________?






Diphenoxylate may cause respiratory depression on administration

86 - Excessive bleeding due to heparin overdose is controlled by______________?






Protamine sultate

87 - Fellypressin is a_______________?






Vaso constrictor

88 - Folic acid deficiency occurs in______________?






Phenytoin

89 - Following analgesic combination should be avoided ?






Ibuprofen and DIclofenac

90 - Following inhibits Cytochrome P450_____________?






Cimetidine

91 - Gastric irritation is minimum with one of the following non-steroidal anti inflammatory drugs_____________?






Meloxicam

92 - Heparin, apart from releasing lypoprotein lipase in the blood exerts its anti-coagulant action by____________?






Inhibiting thrombin synthesis

93 - Heroin, an addict drug contains______________?






Acetyl morphine

94 - Hypokalemia is seen in therapy with____________?






Digitalis

95 - Ibuprofen is contraindicated in_______________?






patients having asthma

96 - Identify the factors which decrease the effect of Oral anticoagulants_______________?






Both A & B

97 - If patient is given Noradrenaline what will happen_______________?






Cause increase in B.P, due to its action on Beta receptors only

98 - In treating Xerostomia, Which of the following might be prescribed ?






Neostigmine

99 - In which of the following categories are ephedrine, tyramine and emphetamine classified________________?






Indirect acting sympathomimetics

100 - Indirect sympathomimetics can_______________?






Both of the above

101 - INFLIXIMAB (systemic) is used in_____________?






All of the above

102 - Ipratropium bromide is used for_____________?






Bronchial asthma

103 - Isosorbide 5 – mononitrate is preferred because____________?






Longer duration of action

104 - IV ultrashort acting barbiturate_____________?






Thiopentone

105 - Less gastrointestinal bleed is seen in the following NSAID_______________?






C0X2 specific inhibitors

106 - Long acting beta – 2 agonist ?






Salmeterol

107 - Magnesium and Aluminium are added in Antacid because_____________?






Mg Causes Diarrhoea, Al Causes Constipation

108 - Mechanism of action of nifidipine is_____________?






It has a prominent smooth muscle relaxant action causes arteolar dilation leading to fall in blood pressure

109 - Mode of action of sulphonyl ureas includes all the following except______________?






Decreasing Glucose absorption from the qut

110 - Morphine a powerful opioid analgesic drug should be avoided in all the following conditions except____________?






A & C

111 - Morphine is a_____________?






Both A & B

112 - Morphine is contraindicated in all of the following except_______________?






Pulmonary oedema

113 - Morphine withdrawal is characterized by all EXCEPT_____________?






Miosis

114 - Narcotic overdose can be antagonized by______________?






Naloxane

115 - Neuromuscular blocking agent with duration of onset of action less than 2 minutes is_________________?






Succinyl choline

116 - Neusea and vomiting that are associated with administration of opioid analgesic is the result of stimulation of the_____________?






Chemoreceptor trigger zone (CTZ)

117 - NSAID which undergoes enterohepatic circulation______________?






Piroxicam

118 - NSAID's have adverse effect on________________?






Stomach

119 - Omeprazol is used in the treatment of____________?






Peptic Ulcer

120 - Omeprazole is a_____________?






Proton pump inhibitor

121 - One of the benzodiazepines (BDZ) comparatively safe in pregnancy is (Category-B) ?






Lorazepam

122 - One of the following is not an antiemetic_____________?






Digitoxin

123 - One of the obious consequences of alchol ( ethenol), ingestion in many individual is facial flushing and increased heart rate triggered off by alcohol getting metabolized to______________?






Acetaldehyde

124 - Paracetamol is contraindicated in_______________?






A & B

125 - Phenothiazines are used to____________?






Alter psychotic behaviour

126 - Phenytoin is associated with_____________?






Folic acid deficiency

127 - Platelet aggregation in inhibited by all except_______________?






Phenobarbitone

128 - Pregnant patient can be safely given______________?






Paracetamol

129 - Prolonged use of aspirin causes_______________?






Hypoprothrombinemia

130 - Prolonged use of aspirin leads to______________?






A & B

131 - Quindine is used to treat______________?






Atrial fibrillation

132 - Quinine is obtained from CINCHONA________________?






Bark

133 - Rebound phenomenon is most commonly seen with use of_________________?






Epinephrine

134 - Respiratory depression is seen with_____________?






Synthetic narcotics

135 - Role of Heparin_____________?






Prevents prothrombin conversion to thrombin

136 - Salbutamol is used in_____________?






Bronchial asthma

137 - Salicylate administration is contraindicated in pregnancy because_______________?






All of these

138 - Salicylate overdose in children causes_______________?






Rye's syndrome

139 - Scopolamine helps in________________?






A & C

140 - Short-acting non-depolarising muscle relaxant is________________?






Mivacurum

141 - Shortest acting opioid analgesic is______________?






Remifentanil

142 - Sialogouges are______________?






Increases salivary secretions

143 - Steroids________________?






Steroids reduce the rate of repair of tissues thus delays the healing

144 - Succinylcholine is a/an______________?






None of the above

145 - Succinylcholine prevents bronchospasm by______________?






Depolarising block

146 - The anticoagulant action of Warfarin is potentiated by all except_____________?






B & C

147 - The anticogulant of choice during pregnancy is______________?






Heparin

148 - The anti-inflammatory analgesic drug the causes least gastrointestinal symptoms is______________?






Paracetamol

149 - The beneficial effect of drug neostigmine in the treatment of Myasthenia gravis is due to the action____________?






It inhibits the action of cholinesterase

150 - The drug which activates plasma antithrombin -III for its anticogulant action is____________?






Heparin

151 - The drug which is contraindicated in haemophilla is_________________?






Aspirin

152 - The Ethyl alcohol (Ethanol) is more effective when mixed with water and used as_____________?






60 to 70 percent

153 - The first choice of drug for patitmal seizure is________________?






None of the above

154 - The following drugs are useful in hypertension except_____________?






Pentoxifyline

155 - The highest risk associated with use of oral contraceptives in________________?






Thromboembolic disorders

156 - The intramuscular administration of 0.6 mg of atropine sulphate to a 50 kg adult may produce all of the following effects except________________?






Bradycardia

157 - The mechanism of action of sodium nitroprusside is_____________?






Direct Vasodilator

158 - The most prominent toxic effect associated with acetominophen use is______________?






Hepatic necrosis

159 - The muscle relaxant effect of succinylcholine lasts for______________?






3-5 min

160 - The potent anti arrhythmic drug which has little negative ionotropic effect valuable in patients with poor left ventricular function_____________?






Digoxin

161 - The principle central action of caffeine is on the________________?






Cerebral cortex

162 - The principle therapeutic action of the glucocorticoid is________________?






Anti-inflammatory

163 - The rate of injection of intravenous Valium is_______________?






1 ml / min

164 - The statement Not true of Selective Cox – 2 inhibitor is________________?






Safe in patients with renal insufficiency

165 - The toxic effect of Beta receptor antagonists includes all the following EXCEPT____________?






Precipitate migrainic effect

166 - Therapeutic uses of a – adrenoceptor blockers include all of the following EXCEPT______________?






Amxiety

167 - Thiopentone action is terminated by______________?






Redistribution

168 - Thyroid storm can be treated by all the following drugs EXCEPT______________?






Aspirin

169 - Triflusal is a___________________?






Antiplatelet drug

170 - True about use of midazolam over diazepam is sedation in all except ?






Binds to benzodiazepine receptors with 3-4 time more avidly

171 - various insulin preparations useful in the treatment of diabetes mellitus differ primarily in______________?






Onset and duration of action

172 - Verril's sign is seen in_________________?






Diazepam administration

173 - Warfarin therapy is prolonged by all except______________?






Rifampicin

174 - Which among the following is a pure antagonist of opioid receptors ?






Natrexone

175 - Which among the following may be used as a sedatives hypnotic ?






Zolpiden

176 - Which among the following Not a pharmacological action of opioids______________?






Anti-emesis

177 - Which is NOT a 2nd generation antihistaminic ?






Cyclizine

178 - Which is not antiemetic ?






Phenazocine

179 - Which of the following anti inflammatory drug is a COX-2 inhibitor_____________?






Rofecoxib

180 - Which of the following anti-epileptic agents causes the reversible side-effect of gingival hyperplasia ?






None of the above

181 - Which of the following antihypertensive agents in most likely to cause an exaggerated response to an injected catecholamine_____________?






Gauanethidine

182 - Which of the following can be given safely to a patient of congestive heart failure________________?






Paracetamol

183 - Which of the following cardiac depressants is contraindicated in a patient with cardiac arrhythmia____________?






Quinidine

184 - Which of the following combination of iron can be given both IM and IV____________?






Iron dextran

185 - Which of the following drug induces parkinsonism ?






Chlorpromazine

186 - Which of the following drug is used to counter act the gastric irritation produced by administration of NSAID_______________?






Misoprostol

187 - Which of the following drugs can be given safely to a patient with renal disease ?






Diazepam

188 - Which of the following drugs causes extra pyramidal symptoms_____________?






Phenothiazines

189 - Which of the following drugs is currently widely used in treating opioid dependent individuals?






Methadone

190 - Which of the following drugs is least efficacious in the treatment of cemporal lobe epilepsy ?






Primidone

191 - Which of the following drugs is not hypoglycemic?






Glibenclamide

192 - Which of the following drugs is used therapeutically during allergic conditions ?






Epinephrine

193 - Which of the following drugs is used to treat both diabetes mellitus and diabetes insipidus_____________?






Chlorpropamide

194 - Which of the following drugs undergoes “Hoffmann elimination" ?






Atracurium

195 - Which of the following general anesthetics is given by intravenous route ?






Propofol

196 - Which of the following is a muscle relaxant_________________?






Pentazocine

197 - Which of the following is a non steroidal anti inflammatory agent with a tendency to produce blood dyscrasias ?






B & C

198 - Which of the following is a nonsteroldad anti inflammatory agent with a tendency to produce blood dyscriasis ?






Indomathecin (indocin)

199 - Which of the following is a peripherally acting muscle relaxant______________?






Succinyl choline

200 - Which of the following is a protective drug in the management of gastric and duodenal ulcers ?






Carbenoxolone

201 - Which of the following is a short acting barbiturate ?






Secobarbital

202 - Which of the following is a vosoconstrictor______________?






None of the above

203 - Which of the following is an ACE inhibitor ?






Coptopril

204 - Which of the following is an irreversible side enact resulting from long term administration of phenothiazline antipsychotics__________________?






B & C

205 - Which of the following is antiasthmatic_____________?






Salbutamol

206 - Which of the following is not a contraindication in the therapy with opioids_____________?






Use in severe constant pain

207 - Which of the following is not an antimigraine agent ?






Zonisamide

208 - Which of the following is NOT an important/frequent/well-known manifestation of an adverse drug reaction ?






Leukaemia

209 - Which of the following is not caused by Frusemide____________?






Hypercalcemia

210 - Which of the following is not true about ACE inhibitors ?






Postural hypotension is seen

211 - Which of the following is true about parasympathetic nervous system ?






Ach is transmitter at both pre & post synaptic junction

212 - Which of the following opioids is not given intrathecally ?






Remifentanil

213 - Which of the following receptors is activated by acetylcholine and blocked by atropine______________?






Muscarinic

214 - Which of the following statements is not correct regarding warfarin_____________?






In a racemic mixture the R form is four times more active than the S form

215 - Which of the following statements regarding nitroglycerin is true ?






All of the above

216 - Which of the following sympathominetic agents is the most bronchodilator_____________?






Isoproterenol

217 - Which of the following synthetic sterioid shows predominantly mineralocorticoid action ?






Fludrocortisone

218 - Which one is not converted to an active metabolite ?






Lisinopril

219 - Which one of the anti hypertensives is contraindicated in pregnancy ?






Enlapril

220 - Which one of the following agents/ drugs is of no value in the post operative care of the hemophiliac patient ?






Clopidogrel

221 - Which one of the following can be blocked by atropine ?






Decreased blood pleasure caused by hexamethonium

222 - Which one of the following does NOT act by increasing insulin secretion______________?






Biguanide

223 - Which one of the following drugs has been shown to offer protection from gastric aspiration syndrome in a patient with symptoms of reflex ?






Metoclopramide

224 - Which one of the following drugs is most commonly employed in an attack of angina pectoris ?






Nitroglycerina

225 - Which one of the following drugs is not a non depolarizing competitive neuromuscular blocker ?






Decamethonium

226 - Which one of the following drugs is not a reversible anticholinesterase drug ?






Carbaryl

227 - Which one of the following drugs is not contraindicated in bronchial asthma ?






Nitroglycerine

228 - Which one of the following is NOT an ergot alkaloids_____________?






Ketanserin

229 - Which one of the following is Not true of angiotensin converting enzyme (ACE) inhibitor____________?






Contraindicated in diabetic nephropathy

230 - Which one of the following muscle relaxant has the maximum duration of action ?






Doxacurium

231 - Which one of the following NSAIDs has adverse effects on liver ?






Acetaminophen

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