1 - 1st past metabolism effect can be observed with which route______________?
1 - 1st past metabolism effect can be observed with which route______________?
Oral
2 - A biological experiment in which one compares the effects of two preparations by means of common biological response is known a_____________?
2 - A biological experiment in which one compares the effects of two preparations by means of common biological response is known a_____________?
Bio-assay
3 - A child has phocomelia, this impliments his mother had taken which of the following medication during pregnancy______________?
3 - A child has phocomelia, this impliments his mother had taken which of the following medication during pregnancy______________?
Thalidomide
4 - A child is brought with drowsiness, decreased deep tendon reflexes and seizures. On examination the child has a blue line on gums. There is history of constipation. Which will be most appropriate drug that should be used in this child ?
4 - A child is brought with drowsiness, decreased deep tendon reflexes and seizures. On examination the child has a blue line on gums. There is history of constipation. Which will be most appropriate drug that should be used in this child ?
EDTA
5 - A drug A & B compared, all are true except____________?
5 - A drug A & B compared, all are true except____________?
Efficacy is not dose dependent
6 - A patient on digoxin should not be given quindine because______________?
6 - A patient on digoxin should not be given quindine because______________?
Displaces digoxine from its tissue binding sites
7 - A prodrug is____________?
7 - A prodrug is____________?
An inactive drug that is transformed in the body to an active metabolite
8 - A side effect of an antithyroid drug is______________?
8 - A side effect of an antithyroid drug is______________?
Hypothyroidism
9 - According to American society of Anesthetists, physical status scale Class III would be_____________?
9 - According to American society of Anesthetists, physical status scale Class III would be_____________?
A patient with severe systemic disease that it not in capacitating
10 - Agents used by local application to control bleeding include all of the following except____________?
10 - Agents used by local application to control bleeding include all of the following except____________?
Vitamin-K
11 - All of the following are tocolytic except_______________?
11 - All of the following are tocolytic except_______________?
Natrexam
12 - All of the following are true except____________?
12 - All of the following are true except____________?
Thalidomide is used for the treatment of leprosy
13 - All of the following penetrate the CSF except________________?
13 - All of the following penetrate the CSF except________________?
Dopamine
14 - All of the following statements regarding biovailability of a drug are true except______________?
14 - All of the following statements regarding biovailability of a drug are true except______________?
Low oral biovailability always and necessarily mean poor absorption
15 - All the following increases drug metabolism by activating cytochrome enzyme, EXCEPT___________?
15 - All the following increases drug metabolism by activating cytochrome enzyme, EXCEPT___________?
Cimetidine
16 - Allergic reactions depends on all except____________?
16 - Allergic reactions depends on all except____________?
Dosage of the drug received
17 - American society of anesthesiologists physical status classification system, P2 is a is a patient who______________?
17 - American society of anesthesiologists physical status classification system, P2 is a is a patient who______________?
With mild systemic disease
18 - Blood spills in hospitals are cleaned by_______________?
18 - Blood spills in hospitals are cleaned by_______________?
Sodium hypochlorite
19 - Combination of ampicillin and gentamicin is an example of_____________?
19 - Combination of ampicillin and gentamicin is an example of_____________?
Synergy
20 - Complete drug elimination occurs after how many hours, if t½ is 4 hrs______________?
20 - Complete drug elimination occurs after how many hours, if t½ is 4 hrs______________?
20 hrs
21 - Dermatologic manifestation of drug allergy are managed by_____________?
21 - Dermatologic manifestation of drug allergy are managed by_____________?
Chlorpheniramine
22 - Drug binds to activate the receptor is same fashion, which directly or indirectly brings effect, is_____________?
22 - Drug binds to activate the receptor is same fashion, which directly or indirectly brings effect, is_____________?
Agonist
23 - Drug efficacy refers to_________________?
23 - Drug efficacy refers to_________________?
Maximal intensity of response that can be produced by the drug
24 - Drug injury may be caused by therapeutic drugs or______________?
24 - Drug injury may be caused by therapeutic drugs or______________?
Nontherapeutic agents
25 - Drug which crosses placental barrier is____________?
25 - Drug which crosses placental barrier is____________?
All of the above
26 - Drugs exhibiting first pass metabolism are all EXCEPT one______________?
26 - Drugs exhibiting first pass metabolism are all EXCEPT one______________?
Salicylates
27 - Drugs showing zero order kinetics of elimination_____________?
27 - Drugs showing zero order kinetics of elimination_____________?
Have a half – life independent of dose
28 - During administration of NSAIDs in children, the most important of dose administration is______________?
28 - During administration of NSAIDs in children, the most important of dose administration is______________?
Weight of the child
29 - Elimination after 4 half lives in first order kinetics is____________?
29 - Elimination after 4 half lives in first order kinetics is____________?
0.93
30 - Filgrastin is used for treatment of_____________?
30 - Filgrastin is used for treatment of_____________?
Neutropenia
31 - Finasteride is a ?
31 - Finasteride is a ?
5 alpha reductase inhibitor
32 - Following drug which undergo most of its metabolism presystemically______________?
32 - Following drug which undergo most of its metabolism presystemically______________?
Propranolol
33 - For Arsenic poisoning Antidote is_____________?
33 - For Arsenic poisoning Antidote is_____________?
B.A.L
34 - Gastric secretion has been shown to be most effectively reduced with the use of___________?
34 - Gastric secretion has been shown to be most effectively reduced with the use of___________?
H2 histamine receptor antagonist
35 - H antagonists are effective in the therapy of all the following except______________?
35 - H antagonists are effective in the therapy of all the following except______________?
Parkinsonism
36 - Hepatic first pass metabolism is important in____________?
36 - Hepatic first pass metabolism is important in____________?
Drugs taken orally
37 - I.V anesthesia is_________________?
37 - I.V anesthesia is_________________?
Propofol
38 - Idiosyncracy is known as to have_____________?
38 - Idiosyncracy is known as to have_____________?
Genetic component
39 - IF patient suffered from exaggerated effect of pharmacological effect____________?
39 - IF patient suffered from exaggerated effect of pharmacological effect____________?
Toxicity
40 - Imatinib acts on______________?
40 - Imatinib acts on______________?
Tyrosin Kinase receptors
41 - Immune mediated qualitative drug intolerance is called______________?
41 - Immune mediated qualitative drug intolerance is called______________?
Hyper sensitivity
42 - In cirrhoses patients, dose reduction is needed for all the following drugs except_____________?
42 - In cirrhoses patients, dose reduction is needed for all the following drugs except_____________?
Lorazepam
43 - Intramuscular route is precluded during the medication of________________?
43 - Intramuscular route is precluded during the medication of________________?
Anticoagulants
44 - Km value indicates______________?
44 - Km value indicates______________?
Half life enzymes drug complex
45 - Loading dose depends on_____________?
45 - Loading dose depends on_____________?
Volume of distribution
46 - Majority of drugs are transported across the membrane by____________?
46 - Majority of drugs are transported across the membrane by____________?
Passive diffusion
47 - Mandibular sublaxation is associated with________________?
47 - Mandibular sublaxation is associated with________________?
Prochlorperazine
48 - Mention the drug causing gynecomastia hirsuitism, menstrual disturbance on long-term use______________?
48 - Mention the drug causing gynecomastia hirsuitism, menstrual disturbance on long-term use______________?
Spironolactone
49 - Neuro adaptation to drug is same as______________?
49 - Neuro adaptation to drug is same as______________?
Physical dependence
50 - Nitrates are not used in______________?
50 - Nitrates are not used in______________?
Renal colic
51 - Not true about penicillin G is______________?
51 - Not true about penicillin G is______________?
More concentrated in prostatic secretions and intraocular fluids
52 - ovidone iodine is the choice of mouthrinse in cases associated AIDS because______________?
52 - ovidone iodine is the choice of mouthrinse in cases associated AIDS because______________?
It is a topical antimicrobial
53 - Patients tend to exhibit a greater than normal response drugs in each of the following conditions except_______________?
53 - Patients tend to exhibit a greater than normal response drugs in each of the following conditions except_______________?
Congestive cardiac failure
54 - Plasma concentration of drug at time 0 is 96g/mL. if t1/2 is 2 hours concentration is plasma at 10 hours will be___________?
54 - Plasma concentration of drug at time 0 is 96g/mL. if t1/2 is 2 hours concentration is plasma at 10 hours will be___________?
3
55 - Potassium permanganate is used for_______________?
55 - Potassium permanganate is used for_______________?
Irrigating cavities
56 - Progestin compound that does not alter lipid profile is______________?
56 - Progestin compound that does not alter lipid profile is______________?
Gestodene
57 - Secretory immunoglobulin is_____________?
57 - Secretory immunoglobulin is_____________?
IgA
58 - Serum sickness is caused by all the following drugs except_____________?
58 - Serum sickness is caused by all the following drugs except_____________?
Chloroquin
59 - Side effect of antihistaminic is_______________?
59 - Side effect of antihistaminic is_______________?
Drowsiness
60 - Sildenafil is inhibitor of_______________?
60 - Sildenafil is inhibitor of_______________?
PDE-5
61 - Teratogenicity is_______________?
61 - Teratogenicity is_______________?
Fetal malformation
62 - Teratogenicity results when drugs are given during____________?
62 - Teratogenicity results when drugs are given during____________?
First trimester
63 - The dose of a drug required to produce a specified effect in 50% of the population is_____________?
63 - The dose of a drug required to produce a specified effect in 50% of the population is_____________?
Ed50
64 - The drug Amifostine is used in subjects undergoing radiotherapy for cancer as it________________?
64 - The drug Amifostine is used in subjects undergoing radiotherapy for cancer as it________________?
Scavanges free radicals
65 - The drug which has an affinity for a receptor site and produces the intrinsic activity of the receptor cell or enzyme system is known as____________?
65 - The drug which has an affinity for a receptor site and produces the intrinsic activity of the receptor cell or enzyme system is known as____________?
An agonist
66 - The drug which has an antabusive effect when alcohol is ingested is______________?
66 - The drug which has an antabusive effect when alcohol is ingested is______________?
Metronidazole
67 - The following statements about verapamil are true except_____________?
67 - The following statements about verapamil are true except_____________?
It is contraindicated in patients with supraventicular tachycardia
68 - The following statements are true about intravenous route of drug administration EXCEPT____________?
68 - The following statements are true about intravenous route of drug administration EXCEPT____________?
Suspensions can be administered
69 - The maximum antiseptic action is seen with which of the following concedntrations of ethanol_____________?
69 - The maximum antiseptic action is seen with which of the following concedntrations of ethanol_____________?
0.7
70 - The most common cause of antibiotic – related diarrhea is____________?
70 - The most common cause of antibiotic – related diarrhea is____________?
C.difficile
71 - The most common type of epilepsy in children is________________?
71 - The most common type of epilepsy in children is________________?
Petit mal
72 - The phase I reactions of drug metabolism include The following except_____________?
72 - The phase I reactions of drug metabolism include The following except_____________?
Conjugation
73 - The ratio of the median lethal dose of the median effective dose is the_____________?
73 - The ratio of the median lethal dose of the median effective dose is the_____________?
Therapeutic index
74 - The vulnerable period of pregnancy for the causation of foetal malformation is_____________?
74 - The vulnerable period of pregnancy for the causation of foetal malformation is_____________?
19 – 55 days
75 - Therapetic index indicates____________?
75 - Therapetic index indicates____________?
Drug safety
76 - Therapeutic index is____________?
76 - Therapeutic index is____________?
LD 50/ED500
77 - Therapeutic uses of calcium salts include the following except_________________?
77 - Therapeutic uses of calcium salts include the following except_________________?
Disorders of coagulation
78 - Toxic optic neuropathy can be caused by all of the following EXCEPT____________?
78 - Toxic optic neuropathy can be caused by all of the following EXCEPT____________?
Ciprofloxacin
79 - Toxic optic neuropathy can be caused by all of the following EXCEPT_______________?
79 - Toxic optic neuropathy can be caused by all of the following EXCEPT_______________?
Ciprofloxacin
80 - Untrue about vitamin D is_______________?
80 - Untrue about vitamin D is_______________?
25-hydroxycholecalciferol is used in treatment of renal failure
81 - Use of morphine is contraindicated in the following conditions except_______________?
81 - Use of morphine is contraindicated in the following conditions except_______________?
Acute myocardial infarcation
82 - What is the advantage of sublingual route of administration of drugs_____________?
82 - What is the advantage of sublingual route of administration of drugs_____________?
prevents or bypasses first pass effects
83 - When a drug creates an effect that is unpredictable and unique it is termed as____________?
83 - When a drug creates an effect that is unpredictable and unique it is termed as____________?
Idiosyncratic effect
84 - When allergic manifestations occur pursuant to use of antimicrobial agents, what of the following is seen____________?
84 - When allergic manifestations occur pursuant to use of antimicrobial agents, what of the following is seen____________?
Both A & B
85 - When given together, the ability of two drugs to produce a response greater than either administered alone is termed as_____________?
85 - When given together, the ability of two drugs to produce a response greater than either administered alone is termed as_____________?
Synergism
86 - Which among the following anti-histamines, is Least likely to cause sedation_____________?
86 - Which among the following anti-histamines, is Least likely to cause sedation_____________?
Loratidine
87 - Which among the following is a cell cycle specific anti-neoplastic drug ?
87 - Which among the following is a cell cycle specific anti-neoplastic drug ?
Methotrexate
88 - Which antisialagogue is contraindicated in glaucoma_____________?
88 - Which antisialagogue is contraindicated in glaucoma_____________?
Atropine
89 - Which drug is not acetylated ?
89 - Which drug is not acetylated ?
Metaclopramide
90 - Which drug is present in ledermix paste ?
90 - Which drug is present in ledermix paste ?
Demeclocyline
91 - Which drugs had high first pass effect_____________?
91 - Which drugs had high first pass effect_____________?
Verapamil
92 - Which is a prodrug ?
92 - Which is a prodrug ?
Enalapril
93 - Which of the following can cause seizure ?
93 - Which of the following can cause seizure ?
Isoniazid
94 - Which of the following drugs cannot reduce the salivary secretions ?
94 - Which of the following drugs cannot reduce the salivary secretions ?
Neostigmine
95 - Which of the following drugs is used in the morning sickness_____________?
95 - Which of the following drugs is used in the morning sickness_____________?
Hyoscine
96 - Which of the following drugs to not require a change in their dosage in patients with renal failure_______________?
96 - Which of the following drugs to not require a change in their dosage in patients with renal failure_______________?
Isoniazid
97 - Which of the following histamine blockers has no effect on muscarinic receptors______________?
97 - Which of the following histamine blockers has no effect on muscarinic receptors______________?
Terfenadine
98 - Which of the following is a leukotriene antagonist ?
98 - Which of the following is a leukotriene antagonist ?
Montelukast
99 - Which of the following is a mismatch ?
99 - Which of the following is a mismatch ?
Naloxone-Tricyclic antidepressant
100 - Which of the following is not a potassium sparing diuretic______________?
100 - Which of the following is not a potassium sparing diuretic______________?
Bumetainde
101 - Which of the following is NOT a systemic effect of corticosteroid ?
101 - Which of the following is NOT a systemic effect of corticosteroid ?
Increase in IL-1
102 - Which of the following is not true for histamine ?
102 - Which of the following is not true for histamine ?
causes bronchodialtion
103 - Which of the following is true for carbonic anhydrase inhibitor ?
103 - Which of the following is true for carbonic anhydrase inhibitor ?
It is used as an adjunct in epilepsy
104 - Which of the following is used in the prophylaxis of migraine ?
104 - Which of the following is used in the prophylaxis of migraine ?
Topiramate
105 - Which of the following statements about Azoles is false ?
105 - Which of the following statements about Azoles is false ?
They affect the metabolism of drugs such as cyclosporine necessitating an increasing in dosage
106 - Which statement is true about carbamazepine ?
106 - Which statement is true about carbamazepine ?
Used in trigeminal neuralgia
107 - Zero order kinetics is seen with_______________?
107 - Zero order kinetics is seen with_______________?
Phenytoin
Pages
No comments:
Post a Comment
Your Valued Comments Help us to improve our site. Thanks